�European Urology, the official journal of the European Association of Urology will be featuring the article 'Effect of nightly versus on-demand vardenafil on recovery of cavernous function in men following bilateral nerve-sparing radical prostatectomy' by F. Montorsi et al.in the October issue, showing for the first meter that vardenafil, a PDE5 inhibitor, is more efficacious when used on-demand in men with erectile disfunction, supporting a shift towards on-demand dosing with PDE5 inhibitors in this patient group. 87 centres across Europe, the US, Canada and South Africa participated between December 2004 and September 2007.
Nerve-sparing group prostatectomy (NSRP) is the gold-standard therapy for prostate gland cancer in men with a life expectancy of 10 age or more than. The risk of erectile dysfunction (ED) following NSRP is significant. This is caused by neuropraxia - the commonly temporary failure of heart conduction in the absence of morphological changes due to compression, ischemia or blunt injury - which inevitably occurs during the procedure. Ultimately this may lead to the development of fibrosis within the corpus cavernosa and cause ED.
To prevent the onset of postoperative ED, the use of phosphodiesterase type 5 (PDE5) inhibitors was introduced. These agents prevent the breakdown of cyclic guanosine monophosphate in cavernosal tissue, which plays a persona in the prevention of cell expiry and fibrosis, and may thus exert a protective effect on cavernosal smooth muscle.
Participants were recruited to this first robustly designed, evidence-based, multi-centre study approximately unitary month before they were scheduled to undergo NSRP. A number of 423 patients completed the study. The inclusion of the on-demand dosing regimen enabled comparison of the presently recommended guidelines for the use of PDE5 inhibitors with a proposed nightly dosing regime, which was suggested to have potential difference positive personal effects on erectile function. The results clearly show that nightly dosing with vardenafil does not have any effect beyond that of on-demand use.
The written report shows that on-demand use of levitra during the treatment period was associated with importantly greater cavernous function and sexual intercourse completion rates compared to placebo. The success rates for the vardenafil on-demand group were also higher than for the nightly group. These data show that the use of on-demand levitra is of greater benefit than nightly treatment in patients following NSRP surgery and, in general, support the on-demand use of PDE5 inhibitors following NSRP surgery over a casual dosing regime. This prompts reconsideration of the current practice of prescribing nightly PDE5 inhibitor therapy, as on-demand purpose of vardenafil is as effective in men with ED following NSRP, a notoriously difficult-to-treat patient population.
Elsevier
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Saturday 6 September 2008
Wednesday 27 August 2008
Pick of the week: Jazz
Gilad Atzmon/National Youth Jazz Orchestra Of Scotland
Fettes College, Edinburgh,
Saturday, Sunday
Fiery saxophone virtuoso brings his existence jazz Orient House Ensemble, while Scotland's young rising stars go through their swing to contemporary paces.
Cathie Rae
Ravelston House Hotel, Musselburgh
Sunday 24
Fine Scottish jazz and standards singer capable of transforming the near familiar materials � much with the help of gifted saxist/ arranger Julian Arguelles.
Martin Taylor
Dundee Repertory Theatre, Dundee
Saturday 23
One-man guitar history-lesson Taylor makes solo guitar playing sound orchestral, and his reworking of Django Reinhardt's music is legendary.
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Thursday 7 August 2008
Streetwize
Artist: Streetwize
Genre(s):
Jazz
Discography:
Sexy Love
Year: 2007
Tracks: 10
A legato jazz studio supergroup lED by saxophonist Kim Waters, Streetwize feature a roll of urban jazz all-stars including isaac Merrit Singer Maysa Leak and guitar player Ken Navarro. The idea of coaction is naught new to jazz -- smooth or otherwise -- the braid here is that Streetwize perform stream rap and R&B wireless hits. Their beginning album, Streetwize: Smooth Urban Jazz, was released by Shanachie in 2002 and featured versions of Mystikal's "Stimulate It Fast," Aaliyah's "Rock the Boat," and D'Angelo's "Brown Sugar." A sec base album, Ferment It, appeared the succeeding year with Kim Waters and company shining the edges off tracks made popular by Missy Elliott, Erykah Badu, and Jennifer Lopez.
Tuesday 1 July 2008
Zion I
Artist: Zion I
Genre(s):
Rap: Hip-Hop
Discography:
Mind over Matter
Year: 2000
Tracks: 21
This triplet of genre-bender pride has made a name for itself on the Bay Area scene by successfully mixing spiritualism and hip-hop. Oakland's MC Zion and DJ/producer Amp Live blend hip-hop and trip-hop beatniks with lyrics focused on a message of wholeness, hope, and religious awareness. After a duet of indie hits, the trio slowly made inroads while opening for pat royalty like De La Soul, Rakim, and Run-D.M.C. Their debut record album, Mind Over Matter, was released in May of 2000 and features collaborations with fellow Bay Area rappers Rasco, Planet Asia, and the Grouch. Although Zion I operates out of Berkeley, the grouping was originally formed in Atlanta, fashioning their music difficult to classify as purely West Coast rap music. Their musical elan makes them fifty-fifty harder to specify. With a trend that borrows from hip-hop, trance, drum'n'bass, and reggae, Zion I's trend is every bit mystical and mystifying.
Knightley happy to appear naked on-screen
Thursday 26 June 2008
Saturday 21 June 2008
Jay-Z Replaced By Shakir Stewart At Def Jam
Island Def Jam has announced the replacement for Jay-Z, following his resignation as the CEO of Def Jam in December last year.
Shakir Stewart has stepped in for the influential hip-hop label, now in its 24th year and his new position includes signing new names, overseeing producers and guiding the creative vision of the label.
Stewart is no stranger to the hip-hop world after working with the company already as the senior VP of A&R, while his early days saw him promoting live shows from Nas, Too $hort and many more.
Elsewhere for other labels, he has been responsible for signing or working with huge names like Destiny's Child, Ciara, Outkast, Usher and more.
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Brian Williams Takes on Meet the Press
NBC Nightly News' Brian Williams has been tapped to assume Tim Russert's moderator chair on Sunday's Meet the Press; however, NBC has yet to decide on a permanent host to replace the late anchor.
Tim passed away from a heart attack on June 13 at the age of 58.
Brian will welcome Sens. Joe Biden, D-Del., and Lindsey Graham, R-S.C., on Sunday. The two were scheduled to appear on Meet the Press last week. Last Sunday's episode, hosted by Tom Brokaw, turned into a special tribute for Tim, who hosted the show for 17 year's, the show's longest-serving anchor. The moderator's chair was left vacant in his honor.
Tim was also NBC's Washington Bureau Chief, another spot the Peacock needs to fill.
Still coming to terms with their devastating loss, NBC is not yet ready to name permanent replacements for either positions. The network plans to rotate in-and-out different hosts for Meet the Press in the coming weeks.
"Tim is truly irreplaceable, and there's no single person who can step in and do all this," NBC News President Capus says. "So we have a considerable list of roles that need to be filled. We're just going to take them one at a time."
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